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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
YWHAH
All Species:
4.55
Human Site:
S25
Identified Species:
7.14
UniProt:
Q04917
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04917
NP_003396.1
246
28219
S25
E
R
Y
D
D
M
A
S
A
M
K
A
V
T
E
Chimpanzee
Pan troglodytes
XP_519163
321
36086
A99
E
R
Y
D
D
M
A
A
A
M
K
N
V
T
E
Rhesus Macaque
Macaca mulatta
XP_001111955
233
26714
E19
W
R
T
V
L
V
T
E
L
N
E
P
L
S
N
Dog
Lupus familis
XP_546936
343
38553
R121
G
A
L
R
R
H
G
R
G
P
H
K
V
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQV8
246
28068
D22
A
E
Q
A
E
R
Y
D
D
M
A
A
A
M
K
Rat
Rattus norvegicus
P68511
246
28193
S25
E
R
Y
D
D
M
A
S
A
M
K
A
V
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505266
247
28347
L25
L
T
I
L
M
L
F
L
W
V
L
Q
V
T
E
Chicken
Gallus gallus
Q5F3W6
247
28212
A25
E
R
Y
D
D
M
A
A
A
M
K
N
V
T
E
Frog
Xenopus laevis
Q6PCG0
247
28255
A25
E
R
Y
D
D
M
A
A
A
M
K
A
V
T
E
Zebra Danio
Brachydanio rerio
Q6PC29
247
28216
A25
E
R
Y
D
D
M
A
A
A
M
K
S
V
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29310
248
28209
D23
A
E
Q
S
E
R
Y
D
D
M
A
Q
A
M
K
Honey Bee
Apis mellifera
XP_391841
247
28058
D22
A
E
Q
A
E
R
Y
D
D
M
A
A
A
M
K
Nematode Worm
Caenorhab. elegans
Q20655
248
28049
D22
A
E
Q
A
E
R
Y
D
D
M
A
A
S
M
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42644
255
28588
E25
E
R
Y
E
E
M
V
E
F
M
E
K
V
A
K
Baker's Yeast
Sacchar. cerevisiae
P34730
273
31043
V25
A
E
R
Y
E
E
M
V
E
N
M
K
A
V
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.9
88.6
60
N.A.
76.8
99.1
N.A.
89.4
86.2
87.8
86.2
N.A.
72.5
76.9
75.8
N.A.
Protein Similarity:
100
71.6
90.2
65
N.A.
86.9
99.5
N.A.
91.5
92.7
93.9
93.1
N.A.
85.8
87.8
86.6
N.A.
P-Site Identity:
100
86.6
6.6
20
N.A.
13.3
100
N.A.
20
86.6
93.3
86.6
N.A.
6.6
13.3
13.3
N.A.
P-Site Similarity:
100
93.3
33.3
20
N.A.
26.6
100
N.A.
33.3
93.3
100
100
N.A.
20
26.6
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60
56.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74.9
70.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
7
0
20
0
0
40
27
40
0
27
40
27
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
40
40
0
0
27
27
0
0
0
0
0
0
% D
% Glu:
47
34
0
7
40
7
0
14
7
0
14
0
0
0
54
% E
% Phe:
0
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
40
20
0
0
34
% K
% Leu:
7
0
7
7
7
7
0
7
7
0
7
0
7
0
0
% L
% Met:
0
0
0
0
7
47
7
0
0
74
7
0
0
27
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
14
0
14
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% P
% Gln:
0
0
27
0
0
0
0
0
0
0
0
14
0
0
0
% Q
% Arg:
0
54
7
7
7
27
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
7
0
0
0
14
0
0
0
7
7
7
0
% S
% Thr:
0
7
7
0
0
0
7
0
0
0
0
0
0
54
0
% T
% Val:
0
0
0
7
0
7
7
7
0
7
0
0
60
7
0
% V
% Trp:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
47
7
0
0
27
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _